Original scientific paper
Diagnostic Value of MPO in Patients Admitted for Suspected Acute Coronary Syndrome- A Study of Adult in Mostar, Bosnia AND Herzegovina
Mirjana Vasilj
; University of Mostar, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
Boris Starčević
; University of Zagreb, University Hospital Dubrava, Zagreb, Croatia
Mile Volarić
; University of Mostar, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
Boris Jelavić
; University of Mostar, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
Miro Leventić
; University of Mostar, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
Danijela Ćuk
; University of Mostar, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
Slavica Ćorić
; University of Mostar, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina
Abstract
We assessed the diagnostic efficacy of plasma Myeloperoxidasis (MPO) alone or in combination with cardiac troponin I (cTnI) for detecting ACS in patients presenting with chest pain initiating within 24 h before the hospital admission. In this prospective cohort study were included all respondents who have visited outpatient clinic of internal diseases, University Hospital Mostar because of chest pain and suspected acute coronary syndrome within 24 h of the onset of the period of 6 months and the total sample consisted of 114 patients. Troponin and myeloperoxidase were significantly positively correlated at the beginning of treatment, myeloperoxidase was significantly positively associated with adverse cardiovascular events during hospitalization and myocardial infarction (P<0.05), with the regression analysis did not show a significant predictor in the development of myocardial infarction (p>0.05). Sensitivity of myeloperoxidase as a valid test detection of myocardial infarction at baseline was 0.15 and specificity was 0.85, suggesting good diagnostic value usable in the clinical practice.
Keywords
myeloperoxidasis; aterosclerosis; coronary artery disease; chest pain; diagnosis
Hrčak ID:
120889
URI
Publication date:
31.3.2014.
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