Original scientific paper

Serum biochemical changes in dromedaries experimentally infected with Trypanosoma evansi and treated with melarsenoxyde cysteamine hydrochloride.

Albert W. Mbaya ; Department of Veterinary Microbiology and Parasitology, Faculty of Veterinary Medicine, University of Maiduguri,, Borno, State, Nigeria
Hussein A. Kumshe ; Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Maiduguri, Borno, State, Nigeria
Harrison K. Dilli ; Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Maiduguri, Borno, State, Nigeria

Abstract

This study was carried out to study the effect of melarsenoxyde cysteamine hydrochloride (Cymelarsan®) in modulating serum biochemical changes in dromedaries experimentally infected with Trypanosoma evansi. A total of twenty dromedaries were used in the study. They were randomly divided into Groups A - D of 5 each. Group A was infected but treated with Cymelarsan® at 0.25 mg/kg body weight. Group B was the infected control; Group C was the uninfected control while Group D was uninfected but treated with Cymelarsan®. Uniform parasitaemia (2.4 ± 0.19) was observed following a pre-patent period of 4 days (Group A and B). Parasitemia increased significantly (P<0.05) to 210.2 ± 1.81 (Groups A) and 200.2 ± 1.77 (Group B) at 20 days post-infection (D.P.I.). Following treatment in Group A, parasitemia was not seen at 32 D.P.I. In Group B it attained a peak count of 400.2 ± 2.50 at day 36 D.P.I. On the one hand, alanineaminotransferase, creatinine, total bilirubin concentrations increased significantly (P<0.05) in the infected dromedaries while on the other serum glucose, and total protein levels decreased significantly (P<0.05). These biochemical changes were however amended to their pre-infection values at 16 D.P.I. in Group A in contrast to Group B. These parameters in Group C and Group D remained fairly constant. In conclusion, the infection caused biochemical changes suggestive of liver and kidney dysfunctions, with muscular wasting, which were amended following treatments with Cymelarsan®.

Keywords

Cymelarsan®; biochemical changes; dromedaries; Trypanosoma evansi

Hrčak ID:

125128

URI

https://hrcak.srce.hr/125128

Publication date:

16.7.2014.

Article data in other languages: croatian

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