Original scientific paper
https://doi.org/10.3325/cmj.2014.55.38
Estrogen receptor 1 gene (TA)n polymorphism is associated with lone atrial fibrillation in men
Karlo Golubić
; Department of Cardiovascular Diseases, University Hospital Center, University of Zagreb, School of Medicine, Zagreb, Croatia
Anton Šmalcelj
; Department of Cardiovascular Diseases, University Hospital Center, University of Zagreb, School of Medicine, Zagreb, Croatia
Jadranka Sertić
; Laboratory for Molecular Diagnostics, Department of Laboratory Diagnostics, University Hospital Center, University of Zagreb, School of Medicine, Zagreb, Croatia
Ljiljana Juričić
; Laboratory for Molecular Diagnostics, Department of Laboratory Diagnostics, University Hospital Center, University of Zagreb, School of Medicine, Zagreb, Croatia
Abstract
Aim To determine the association between the number
of thymine-adenine (TA)n dinucleotide repeats in the promoter
region of the gene coding for the estrogen receptor
alpha (ESR1) and the prevalence of lone atrial fibrillation
(AF) in men.
Methods We conducted a case-control study involving 89
men with lone AF and 166 healthy male controls. The ESR1
genotype was established by polymerase chain reaction
and capillary electrophoresis. To assess the association of
ESR1 genotype with AF, logistic regression models were
built with AF as outcome.
Results Men with lone AF had significantly greater
number of (TA)n repeats of single alleles than controls
(mean ± standard deviation, 19.2 ± 4.2 vs 18 ± 4.3, P = 0.010).
After adjustment for other factors, a unit-increase in (TA)n
repeat number was associated with a significantly greater
likelihood of AF (odds ratio 1.069; 95% confidence interval
1.024-1.116, P = 0.002).
Conclusions Our results indicate that a greater number of
(TA)n repeats in the promoter region of ESR1 is associated
with a significantly increased likelihood of lone atrial fibrillation
in men.
Keywords
Hrčak ID:
127272
URI
Publication date:
15.2.2014.
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