Croatica Chemica Acta, Vol. 75 No. 1, 2002.
Original scientific paper
A Physico-chemical Study of the Interaction of Cobalt(II) Ion with Ciprofloxacin
Marija Zupančič
; Faculty of Chemistry and Chemical Technology, University of Ljubljana, Aškerčeva 5, POB 537, 1000 Ljubljana, Slovenia
Iztok Arčon
; Nova Gorica Polytechnic, Vipavska 13, 5000 Nova Gorica, Slovenia
Peter Bukovec
; Faculty of Chemistry and Chemical Technology, University of Ljubljana, Aškerčeva 5, POB 537, 1000 Ljubljana, Slovenia
Alojz Kodre
; Institute Jozef Stefan, Jamova 39, 1000 Ljubljana, Slovenia
Abstract
Reaction between the quinolone antibacterial agent Ciprofloxacin (abbreviation cfH) and Co11 in aqueous medium was studied. The ability of Ciprofloxacin to form metal complexes is highly dependent on the pH value of the solution. UV spectroscopy and solubility of Ciprofloxacin • HC1 were used to determine the optimal conditions for complex isolation in the pH region between 5 and 10, where the solubility of quinolones is very low. The isolated complex [Co(cf)2]× 3H20 was characterized by elemental analysis, FAB-MS, TG analysis, IR spectroscopy and magnetic measurements. Cobalt K-edge EXAFS was used for the Identification of the Co site in the complex.
Keywords
quinolone; Ciprofloxacin; metal-ion complexation; cobalt
Hrčak ID:
127479
URI
Publication date:
4.2.2002.
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