Short communication, Note

https://doi.org/10.1515/acph-2015-0012

Release of rosmarinic acid from semisolid formulations, and its penetration through the human skin ex vivo

ADA STELMAKIENĖ ; Department of Clinical Pharmacy, Lithuanian University of Health Sciences, Kaunas, Lithuania
KRISTINA RAMANAUSKIENĖ ; Department of Clinical Pharmacy, Lithuanian University of Health Sciences, Kaunas, Lithuania
VITALIS BRIEDIS ; Department of Clinical Pharmacy, Lithuanian University of Health Sciences, Kaunas, Lithuania

Abstract

The aim of this study was to evaluate the release of rosmarinic acid (RA) from the experimental topical formulations with the Melissa officinalis L. extract and to evaluate its penetration through undamaged human skin ex vivo. The results of the in vitro release study showed that higher amounts of RA were released from the emulsion vehicle when lemon balm extract was added in its dry form. An inverse correlation was detected between the released amount of RA and the consistency index of the formulation. Different penetration of RA into the skin may be influenced by the characteristics of the vehicle as well as by the form of the extract. The results of penetration assessment showed that the intensity of RA penetration was influenced by its lipophilic properties: RA was accumulating in the epidermis, while the dermis served as a barrier, impeding its deeper penetration.

Keywords

human skin penetration; rosmarinic acid; rheology; release

Hrčak ID:

128991

URI

https://hrcak.srce.hr/128991

Publication date:

30.6.2015.

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