Original scientific paper

https://doi.org/10.5562/cca2399

Effect of Adamantyl Compounds on Dynamics of Spin Labelled Multilamellar Liposomes

Krunoslav Mirosavljević ; College of Slavonski Brod, Dr. Mile Budaka 1, HR-35000 Slavonski Brod, Croatia;Department of Physical Chemistry, Ruđer Bošković Institute, Bijenička cesta 54,10000 Zagreb, Croatia
Marija Matković ; Department of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb
Kata Mlinarić-Majerski ; Department of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb
Vesna Noethig-Laslo ; Department of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb

Abstract

Interactions of two adamantyl molecules: 3-(adamantan-1-yl)propan-1-aminium chloride
(compound A) and 1-hydroxyadamantan (compound B) with multilayer liposomes composed of
L-α-phosphatidylcholine, cholesterol and dicetylphosphate, spin labelled with n-doxylstearic acids (n = 5, 7, 10, 12, 16) were investigated. In the presence of aminium salt (A) or alcohol (B) the increased dy-namics of 5-doxylstearic acids and 16-doxylstearic acids in the multilamellar liposomes were determined in the temperature range from 250 K to 295 K. The increased dynamics of 5-doxylstearic acids suggest-ed that both adamantyl compounds influenced molecular motions in the interfacial region of the lipo-some. The increased motional properties of 16-doxylstearic acids, located in the core of the multilamel-lar liposomes, suggested that both adamantyl compounds induced the structural changes in the hydro-phobic core as well.

Keywords

adamantyl compounds; drug transport; drug interactions; physicochemical properties; spin labelling; ESR; spectroscopy; liposomes; phospholipids

Hrčak ID:

130519

URI

https://hrcak.srce.hr/130519

Publication date:

18.11.2014.

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