Croatica Chemica Acta, Vol. 71 No. 3, 1998.
Conference paper
Structural Studies on the Interactions between Metal Ions and Biological Macromolecules
Pierluigi Orioli
; Department of Chemistry, University of Florence, Via Capponi 7, 50121 Florence, Italy
Abstract
The essential role of metal ions in biology is stressed by structural investigations on two metalloenzymes: human carbonic anhydrase (CA) and Cu, Zn superoxide dismutase (SOD). The X-ray structure of CA complex with histamine affords a satisfactory explanation of the mechanism of activation of CA. The high resolution (1.02 Å) crystal structure of a mutant monomeric Cu, Zn superoxide dismutase gives relevant information on the mechanism of the catalytic activity of the native dimeric enzyme and on the reduced activity of the monomer.
Keywords
Hrčak ID:
132377
URI
Publication date:
1.10.1998.
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