Original scientific paper

Disposition kinetics, renal clearance and urinary excretion of kanamycin in goats.

Asma Nafeesa ; Department of Chemistry, University of Agriculture, Faisalabad, Pakistan
Ataka Rashid ; Department of Chemistry, University of Agriculture, Faisalabad, Pakistan
Tahira Iqbal ; Department of Chemistry, University of Agriculture, Faisalabad, Pakistan
Munir A. Sheikh ; Department of Chemistry, University of Agriculture, Faisalabad, Pakistan
Muhammad Nawaz ; Department of Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan

Abstract

The disposition kinetics, renal clearance and urinary excretion of kanamycin were investigated in eight female goats following intravenous injection of a single dose 5 mg/kg body mass. Based on Cp=Ae-at+Be-ßt, elimination half life of the drug was 2.87±0.12 hours, volume of distribution (Vd(area)) 0.58±0.03 l/kg and total body clearance was 2.39±0.19 ml/min kg. The renal clearance of endogenous creatinine was 1.28±0.40 ml/min kg and kanamycin was 0.33±0.14 ml/min kg being about one fourth of the filtration clearance. Renal clearance was 13.8% of the total body clearance. The renal excretory mechanisms involved glomerular filtration, excreting only 10.3% of the intravenous dose of kanamycin through urine

Keywords

kanamycin; disposition kinetics; renal clearance; urinary excretion; goat

Hrčak ID:

133792

URI

https://hrcak.srce.hr/133792

Publication date:

21.10.1999.

Article data in other languages: croatian

Visits: 1.213 *