Original scientific paper

Solvent and Temperature Effects in π-Route Cyclization

Kata Mlinarić-Majerski ; Department of Chemistry and Biochemistry, Ruder Bošković Institute, 10000 Zagreb, Croatia
Saša Kazazić ; Department of Chemistry and Biochemistry, Ruder Bošković Institute, 10000 Zagreb, Croatia
Marijana Vinković ; Department of Chemistry and Biochemistry, Ruder Bošković Institute, 10000 Zagreb, Croatia
Goran Kragol ; Department of Chemistry and Biochemistry, Ruder Bošković Institute, 10000 Zagreb, Croatia

Abstract

endo-Bicyclo[3.3.1]non-6-ene-3-carboxylic acid (1) was prepared and the solvent and temperature effects on the n-route cyclization were studied. The stereochemistry of the products strongly depends on the reaction temperature and the solvent used. The interpretation of the mechanism and product distribution based on experimental data is supported by theoretical investigation.

Keywords

Hrčak ID:

135973

URI

https://hrcak.srce.hr/135973

Publication date:

2.12.1996.

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