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Archives of Industrial Hygiene and Toxicology, Vol. 66 No. 1, 2015.

Original scientific paper

https://doi.org/10.1515/aiht-2015-66-2515

Effects of chronic exposure to lead, cadmium, and manganese mixtures on oxidative stress in rat liver and heart

Iwona Markiewicz-Górka ; Department of Hygiene, Wroclaw Medical University, Wroclaw, Poland
Lidia Januszewska ; Department of Hygiene, Wroclaw Medical University, Wroclaw, Poland
Aleksandra Michalak ; Department of Hygiene, Wroclaw Medical University, Wroclaw, Poland
Adam Prokopowicz ; Institute of Occupational Medicine and Environmental Health in Sosnowiec, Poland
Ewa Januszewska ; Hospital in Rheinfelden, Rheinfelden, Switzerland
Natalia Pawlas ; Institute of Occupational Medicine and Environmental Health in Sosnowiec, Poland
Krystyna Pawlas ; Department of Hygiene, Wroclaw Medical University, Wroclaw, Poland

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Abstract

The aim of this study was to assess the effects of chronic combined exposure to low, environmental doses of Cd, Pb, and Mn on oxidative stress in the liver and heart of rats and on their liver function parameters. Male Wistar rats were divided randomly into eight groups. For nine months controls were receiving drinking water alone, whereas the exposed groups were receiving drinking water with Pb (0.2 mg L-1), Cd (1 mg L-1), and Mn (2 mg L-1) alone or in combinations. Malondialdehyde (MDA) significantly increased in both heart and liver of the animals after combined exposure to metals. Heart MDA correlated with blood Cd, Pb, and Mn and liver MDA with blood Cd. Aspartate aminotransferase (AST) activity and bilirubin concentration also increased significantly in the animal group exposed to all three metals and correlated positively with blood Cd, Pb, and Mn. Our study has confirmed the synergistic effect of the Cd, Mn, and Pb combination on the increase in heart MDA. A similar synergy was observed for Pb+Mn in the increase of serum alanine aminotransferase (ALT) activity as an indicator of liver function.

Keywords

alanine aminotransferase; aspartate aminotransferase; antioxidant enzymes; bilirubin; heavy metals; long-term poisoning

Hrčak ID:

136511

URI

https://hrcak.srce.hr/136511

Publication date:

18.3.2015.

Article data in other languages: croatian

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