Croatica Chemica Acta, Vol. 68 No. 3, 1995.
Conference paper
Interaction of the Escherichia coli host and phage λ: Role of the RecBCD-Gam complex
Željko Trgovčević
; Ruđer Bošković Institute, HR-10 000 Zagreb, Croatia
Erika Salaj-Šmic
; Ruđer Bošković Institute, HR-10 000 Zagreb, Croatia
Abstract
Biochemical experiments have suggested that the Gam protein from phage X inhibits all the catalytic activities of the RecBCD enzyme of Escherichia coli. The genetic data are at variance with these experiments. The RecBCD-binding Gam protein has profound effects on the physiology of phage X and its host. These effects cannot be explained by the inhibitory action of Gam; the RecBCD-Gam complex apparently retains certain enzymatic activities. The mechanism by which its activities aid a substantial fraction of the phage to escape the EcoK restriction is proposed.
Keywords
Hrčak ID:
136718
URI
Publication date:
1.9.1995.
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