Biochemia Medica, Vol. 25 No. 1, 2015.
Review article
https://doi.org/10.11613/BM.2015.004
Pathologic patterns of interleukin 10 expression – A review
Jasenka Trifunović
orcid.org/0000-0002-0870-821X
; Department of Medical Biochemistry, Special Hospital for Medical Rehabilitation Varaždinske Toplice, Varaždinske Toplice, Croatia
Larisa Miller
; Center of Excellence Medical Publications, EMD Serono Research and Development Institute, Billerica, United States of Americ
Željko Debeljak
; Department of Clinical Laboratory Diagnostics, Clinical Hospital Centre Osijek, Osijek, Croatia
Vesna Horvat
; Department of Clinical Laboratory Diagnostics, Clinical Hospital Centre Osijek, Osijek, Croatia
Abstract
Interleukin 10 (IL-10) is important pleiotropic immunoregulatory cytokine which gene is located on chromosome 1 at 1q31-32. There are many genetic variants of IL-10 gene. However, the most studied are two dinucleotide repeats (microsatellites), IL10.G and IL10.R, located 1.2 kb and 4 kb upstream of the transcription start site and three single nucleotide polymorphisms (SNPs) -1082(G/A), -819(C/T) and -592(C/A). A large number of studies have shown that IL-10 gene polymorphisms are associated with different diseases and play an important role in pathophysiology and clinical course of these diseases. This review summarizes published literature knowledge about the association of IL-10 polymorphisms and expression patterns with asthma, systemic lupus erythematosus, psoriasis, inflammatory bowel disease, rheumatoid arthritis, tuberculosis and some neoplasms
Keywords
autoimmune diseases; inflammatory diseases; interleukin 10; neoplasms; polymorphisms, genetic
Hrčak ID:
139256
URI
Publication date:
15.2.2015.
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