Original scientific paper
https://doi.org/10.3325/cmj.2015.56.152
Modest genetic influence on bronchodilator response: a study in healthy twins
David Laszlo Tarnoki
; Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary
Emanuela Medda
; National Centre for Epidemiology Surveillance and Health Promotion Istituto Superiore di Sanità, Rome Italy
Adam Domonkos Tarnoki
; Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary
Andras Bikov
; Department of Pulmonology, Semmelweis University, BudapestHungary
Zsofia Lazar
; Department of Pulmonology, Semmelweis University, BudapestHungary
Corrado Fagnani
; National Centre for Epidemiology Surveillance and Health Promotion Istituto Superiore di Sanità, Rome Italy
Maria Antonietta Stazi
; National Centre for Epidemiology Surveillance and Health Promotion Istituto Superiore di Sanità, Rome Italy
Kinga Karlinger
; Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary
Zsolt Garami
; The Methodist Hospital, DeBakey Heart & Vascular Center, Houston, TX, USA
Viktor Berczi
; Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary
Ildiko Horvath
; Department of Pulmonology, Semmelweis University, Budapest Hungary
Abstract
Aim To determine the reasons for large standard deviation of
bronchodilator response (BDR) and establish whether there
is a potential heritable component in healthy subjects.
Methods 67 monozygotic and 42 dizygotic adult twin
pairs were assessed for bronchodilator response (% change
in FEV1 after inhaling 400 μg salbutamol). Univariate quantitative
genetic modeling was performed.
Results Multiple regression modeling showed a significant
association between BDR and sex and baseline FEV1
(P < 0.05), while no association was found with smoking
habits, body mass index, or age. Within pair correlation in
monozygotic twins was modest (0.332), but higher than
in dizygotic twins (0.258). Age-, sex-, and baseline FEV1-
adjusted genetic effect accounted for 14.9% (95% confidence
interval, CI 0%-53.1%) of the variance of BDR,
shared environmental effect for 18.4% (95% CI 0%-46.8%),
and unshared environmental effect for 66.8% (95% CI
46.8%-88.7%).
Conclusion Our twin study showed that individual differences
in BDR can be mostly explained by unshared environmental
effects. In addition, it is the first study to show
low, insignificant hereditary influences, independently
from sex, age, and baseline FEV1.
Keywords
Hrčak ID:
139307
URI
Publication date:
15.4.2015.
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