Review article

Chronic kidney disease mineral bone disorder

DRAŠKO PAVLOVIĆ orcid.org/0000-0002-2380-869X ; Department of Nephrology and Dialysis Sestre Milosrdnice University Hospital, Vinogradska c.29, 10000 Zagreb, Croatia
DAJANA KATIČIĆ ; Department of Nephrology and Dialysis Sestre Milosrdnice University Hospital, Vinogradska c.29, 10000 Zagreb, Croatia
TONKO GULIN ; Department of Nephrology and Dialysis Sestre Milosrdnice University Hospital, Vinogradska c.29, 10000 Zagreb, Croatia
JOSIPA JOSIPOVIĆ ; Department of Nephrology and Dialysis Sestre Milosrdnice University Hospital, Vinogradska c.29, 10000 Zagreb, Croatia
LIDIJA ORLIĆ ; Department of Nephrology Dialysis and Kidney Transplantation University Hospital Centre, Rijeka, Croatia

Abstract

Chronic kidney disease – mineral bone disease (CKD-MBD) is a syndrome
defined as a systemic mineral metabolic disorder associated with
CKD. The term renal osteodystrophy, as a part of CKD-MBD, indicates a
pathomorphological concept of bone lesions. High morbidity and mortality
of CKD patients is a consequence of CKD-MBD. The pathogenesis of this
syndrome is not completely understood, but undoubtedly the development of mineral and bone disorder begins in the earliest stages of CKD. The diagnosis is made by non-invasive methods (biochemistry, x-ray, ultrasound, etc.) and bone biopsy as an invasive method. In addition to new drugs, e.g. non-calcium phosphate binders, vitamin D analogs, calcimimetics, prevention and treatment is still a major challenge for the nephrologist. In this article we will briefly discuss the pathophysiology, diagnosis, prevention and treatment of CKD-MBD.

Keywords

chronic kidney disease; bone disease; mineral disorder

Hrčak ID:

139526

URI

https://hrcak.srce.hr/139526

Publication date:

31.3.2015.

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