Original scientific paper
https://doi.org/10.1515/aiht-2015-66-2623
Comparative determination of the efficacy of bispyridinium oximes in paraoxon poisoning
Suzana Žunec
orcid.org/0000-0002-7710-8250
; Institute for Medical Research and Occupational Health, Zagreb, Croatia
Božica Radić
; Institute for Medical Research and Occupational Health, Zagreb, Croatia
Kamil Kuča
; Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
Kamil Musilek
; Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
Ana Lucić Vrdoljak
; Institute for Medical Research and Occupational Health, Zagreb, Croatia
Abstract
The inability of standard therapy to provide adequate protection against poisoning by organophosphorus compounds (pesticides and nerve agents) motivated us to search for new, more effective oximes. We investigated the pharmacotoxicological properties of six experimental K-oximes (K027, K033, K048, K074, K075, and K203) in vivo. The therapeutic efficacy of K-oximes (at doses of 5 or 25 % of their LD50) combined with atropine was assessed in paraoxon-poisoned mice and compared with conventionally used oximes HI-6 and TMB-4. The bisoxime K074 was the most toxic (LD50=21.4 mg kg-1) to mice, while monoxime K027 was the least toxic (LD50=672.8 mg kg-1). With the exception of K033, all of the tested K-oximes showed better therapeutic efficiency than HI-6 and TMB-4. K027 and K048 stood out by demonstrating low acute toxicities and ensuring protective indices ranging from 60.0 to 100.0 LD50 of paraoxon. Taking into account that these two oximes showed a similar therapeutic efficacy regardless of the applied doses, our results suggest that K027 and K048 could be antidotes for paraoxon intoxication.
Keywords
acute toxicity; mice; therapeutic efficacy
Hrčak ID:
139886
URI
Publication date:
16.6.2015.
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