Original scientific paper

Effect of tolfenamic acid co-administration on pharmacokinetics of cefquinome following intramuscular administration in sheep.

Mayankkumar P. Rana ; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat, India
Kamlesh A. Sadariya ; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat, India
Aswin M. Thaker ; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, Gujarat, India

Abstract

The pharmacokinetics of cefquinome (2 mg/kg) were studied following intramuscular administration of cefquinome alone, and co-administered with tolfenamic acid (2 mg/kg) in sheep. The plasma concentration of cefquinome was detected by High Performance Liquid Chromatography. Following a single dose intramuscular administration of cefquinome alone, the peak plasma concentration (Cmax) was 4.36 ± 0.10 μg/mL obtained at 0.75 h. The absorption half-life (t1/2Kα), volume of distribution (Vdarea), total body clearance (ClB) and elimination half-life (t1/2β) of cefquinome were 0.61 ± 0.10 h,2.07 ± 0.36 L/kg, 0.12 ± 0.01 L/h/kg and 12.29 ± 2.62 h, respectively. Following intramuscular co-administration of tolfenamic acid, no significant changes were observed in most of the pharmacokinetic parameters of cefquinome, except Cmax and the absorption rate constant (Ka) were significantly increased, while t1/2 Kα was significantly reduced compared to cefquinome alone treatment of sheep. Cefquinome pharmacokinetic data (2 mg/kg) generated from the present study suggest that cefquinome may be administered with tolfenamic acid to treat bacterial infection with inflammatory conditions in sheep.

Keywords

pharmacokinetics; cefquinome; tolfenamic acid; sheep

Hrčak ID:

140999

URI

https://hrcak.srce.hr/140999

Publication date:

26.6.2015.

Article data in other languages: croatian

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