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Acta clinica Croatica, Vol. 54. No. 1., 2015.

Review article

The Novella about Diabetic Nephropathy

Renata Ivanac-Janković ; Department of Internal Medicine, Bjelovar General Hospital, Bjelovar, Croatia
Vesna Lovčić ; Department of Internal Medicine, Bjelovar General Hospital, Bjelovar, Croatia
Saša Magaš ; Department of Neurology, Bjelovar General Hospital, Bjelovar, Croatia
Duška Šklebar ; Department of Neurology, Bjelovar General Hospital, Bjelovar, Croatia
Petar Kes ; Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, Zagreb University Hospital Center, School of Medicine, University of Zagreb, Zagreb, Croatia

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Abstract

Diabetic nephropathy is a common complication in patients with diabetes mellitus and one of the major reasons for renal replacement therapy in Croatia, Europe and the United States. It is characterized by proteinuria, decline in glomerular filtration, hypertension, and high risk of cardiovascular morbidity and mortality. Deterioration of renal function in diabetic nephropathy develops through five clinical stages characterized by the respective histologic description. Genetic susceptibility, hyperglycemia, high blood pressure and duration of diabetes mellitus definitely play a role in the pathogenetic sequence. Early diagnosis, appropriate patient follow up and treatment are essential to improve the outcomes. Interdisciplinary approach and close collaboration of nephrologists and diabetologists are essential for timely detection of disease progression. Tight glycemic control under the supervision of diabetologists, screening of patients, and once a year report of albuminuria and glomerular filtration allow for detection of renal damage in the early stages and timely referral to a nephrologist. The points of interest given in this overview are description of clinical staging in relation to pathologic classification, repetition of basic causal features, and brief analysis of treatment.

Keywords

Diabetic nephropathy – diagnosis; Diabetic nephropathy – therapy; Albuminuria; Kidney transplantation; Review

Hrčak ID:

141608

URI

https://hrcak.srce.hr/141608

Publication date:

1.3.2015.

Article data in other languages: croatian

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