Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?

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Archives of Industrial Hygiene and Toxicology, Vol. 56 No. 2, 2005.

Professional paper

Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?

Simona Bussi
Alberto Morisetti

Full text: english pdf 73 Kb

page 157-160

downloads: 2.324

APA 6th Edition

Bussi, S. & Morisetti, A. (2005). Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?. Arhiv za higijenu rada i toksikologiju, 56 (2), 157-160. Retrieved from https://hrcak.srce.hr/144

MLA 8th Edition

Bussi, Simona and Alberto Morisetti. "Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?." Arhiv za higijenu rada i toksikologiju, vol. 56, no. 2, 2005, pp. 157-160. https://hrcak.srce.hr/144. Accessed 25 Apr. 2024.

Chicago 17th Edition

Bussi, Simona and Alberto Morisetti. "Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?." Arhiv za higijenu rada i toksikologiju 56, no. 2 (2005): 157-160. https://hrcak.srce.hr/144

Harvard

Bussi, S., and Morisetti, A. (2005). 'Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?', Arhiv za higijenu rada i toksikologiju, 56(2), pp. 157-160. Available at: https://hrcak.srce.hr/144 (Accessed 25 April 2024)

Vancouver

Bussi S, Morisetti A. Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?. Arh Hig Rada Toksikol. [Internet]. 2005 [cited 2024 April 25];56(2):157-160. Available from: https://hrcak.srce.hr/144

IEEE

S. Bussi and A. Morisetti, "Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?", Arhiv za higijenu rada i toksikologiju, vol.56, no. 2, pp. 157-160, 2005. [Online]. Available: https://hrcak.srce.hr/144. [Accessed: 25 April 2024]

Abstract

The margin of safety of a drug is defined as the ratio between toxicity in animals and safety in humans. For intravascular contrast media, the margin of safety is traditionally the ratio between LD50 and diagnostic dose, both doses being based on bodyweight. The shift to surface area dramatically reduces this margin to unacceptable values. Toxicokinetics, which relates systemic exposure associated with early toxic signs in animals to plasma level in man, seems the most accurate and predictive criterion.

Keywords

acute toxicity; diagnostic dose; LD50; toxicokinetics

Hrčak ID:

144

URI

https://hrcak.srce.hr/144

Publication date:

23.5.2005.

Article data in other languages: croatian

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