Short communication, Note
Metal exposure studies: role of toxicology and epidemiology in public health policy
Marko Šarić
; Institute for Medical Research and Occupational Health, Zagreb, Croatia
Martina Piasek
; Institute for Medical Research and Occupational Health, Zagreb, Croatia
Abstract
Following the idea of interrelated role of epidemiology and toxicology in risk assessment and dose response evaluation, this paper presents certain experiences from ihe authors' studies of health effects of environmental exposure to lead and manganese. Epidemiologic observations of adverse effects on female reproductive integrity in a lead smeltery area agree with the experimental data animal studies show that the adverse reproductive effects in females are time and dose-related, and reversible after exposure has ceased. Field studies show that effects of manganese on the respiratory system in a polluted region are dose, age and season-related. Cytotoxic effects of manganese, including the inhibitory effect on alveolar macrophages described in in vitro studies on mammalian cells confirm the epidemiologic observations. Authors conclude that in the process of risk assessment, toxicology and epidemiology have to act together. Available human data should be combined with experimental findings and data on the mechanism of toxic action.
Keywords
cytotoxic effects; lead exposure; manganese exposure; reproductive effects; respiratory effects
Hrčak ID:
144361
URI
Publication date:
13.2.1998.
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