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Chemical and Biochemical Engineering Quarterly, Vol. 29 No. 3, 2015.

Original scientific paper

https://doi.org/10.15255/CABEQ.2014.2092

Synthesis and Characterization of β-Cyclodextrin/alginate Nanoparticle as a Novel Drug Delivery System

T.-D. Nguyen orcid id orcid.org/0000-0001-6330-8916 ; a)Department of Pharmaceutical Chemistry Technology, Institute of Chemical Technology, Vietnam Academy of Science and Technology, 1 Mac Dinh Chi Street, District 1, Ho Chi Minh City, Vietnam; b)Department of Chemistry, Konkuk University, 1 Hwayang-dong, G
T. Hong-Ngan Tran ; Department of Pharmaceutical Chemistry Technology, Institute of Chemical Technology, Vietnam Academy of Science and Technology, 1 Mac Dinh Chi Street, District 1, Ho Chi Minh City, Vietnam
C.-H. Nguyen ; Department of Pharmaceutical Chemistry Technology, Institute of Chemical Technology, Vietnam Academy of Science and Technology, 1 Mac Dinh Chi Street, District 1, Ho Chi Minh City, Vietnam
C. Im ; Department of Chemistry, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143–701, South Korea
C.-H. Dang ; Department of Pharmaceutical Chemistry Technology, Institute of Chemical Technology, Vietnam Academy of Science and Technology, 1 Mac Dinh Chi Street, District 1, Ho Chi Minh City, Vietnam

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Abstract

The aim of this work was to study a novel nanoparticle system formed from alginate and β-cyclodextrin by ionotropic gelation method and to evaluate their potential for the association and delivery of drugs. The nanoparticles were prepared by electrostatic interactions between Ca2+/alginate gel and β-cyclodextrin. Morphology and structure characterization of nanoparticles was investigated by scanning electron micrographs (SEM), transmission electron microscope (TEM), Fourier transform infrared spectra (FTIR). The nanoparticle size was about 50 – 80 nm and their structure quite regular and consistent.
Ketoprofen, chosen as a model drug, was incorporated into the nanocarriers with association efficiency of 50.7 % and loading efficiency of 5.7 %. Ketoprofen released from the nanoparticles was 57 % at pH 7.4 and 69 % at pH 5.0 for 4 h.

Keywords

nanoparticle; nanocarrier; drug delivery; β-cyclodextrin; alginate; ketoprofen; drug release

Hrčak ID:

147008

URI

https://hrcak.srce.hr/147008

Publication date:

14.10.2015.

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