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THE ROLE OF THERAPEUTIC DRESSINGS WITH SILVER IN CHRONIC WOUNDS THERAPY
MAJA MIHELIČ
; University of Ljubljana, Medical Faculty, Ljubljana, Slovenia
TANJA PLANINŠEK RUČIGAJ
; University Medical Centre, Dermatovenerological clinic, Ljubljana, Slovenia
Abstract
Healing is a complex process itself; however, impaired healing of chronic wounds is even more dificult and associated with imbalance of a number of factors. of them, most prominent are inlammatory cytokines, free radicals, proteases, especially matrix metalloproteinases and their tissue inhibitors. Silver is very useful in dificult cases as it supports wound healing in many ways. furthermore, it is known to protect growth factors, scavenge matrix metalloproteinases and free radicals and inactivate destructive proteases, along with other favorable actions. It exerts antimicrobial and anti-inlammatory effects. In low concentrations, it protects from recurrent infections, which is very important for patients at risk, such as those with diabetes, burns and impaired immunity. five patients with different etiology and duration of venous ulcers were included in a small clinical trial. Silver dressing (Promogran Prisma™, Johnson & Johnson) was chosen as the treatment of choice. Ulcer size was reduced by a mean of 34.11% in 17 days of trial, with maximum reduction of 90.91% within 7 days. Accordingly, silver has important effects on the healing process in non-healing wounds of different etiology.
Keywords
silver dressings; chronic wounds
Hrčak ID:
148114
URI
Publication date:
8.11.2015.
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