Professional paper

Imipenem Consumption and Gram-Negative Pathogen Resistance to Imipenem at Sestre Milosrdnice University Hospital

Ines Benčić
Ivan Benčić
Dina Vukičević-Baudoin

Abstract

The study was performed to determine the consumption of imipenem and resistance of gram-negative pathogens (Pseudomonas aeruginosa, Acinetobacter sp., Klebsiella sp., Escherichia coli, Proteus mirabilis, Serratia marcescens, Enterobacter sp.) to imipenem. Gram-negative pathogens were isolated at the Sestre milosrdnice University Hospital from Zagreb in 1999 and 2000. The imipenem sensitivity testing was performed by disk diffusion and E-test methods. The consumption of imipenem was expressed in DDD/100 hospital days in the same periods. Imipenem resistance of Acinetobacter sp. decreased significantly in the year 2000 (p=0.0052), especially in the first six months (p=0.021) when the lowest consumption of imipenem was recorded. Imipenem resistance of other gram-negative pathogens did not decrease significantly. Results suggest that the consumption of imipenem might lead to changes in resistance to imipenem among Acinetobacter strains.

Keywords

Gram-negative bacterial infections; Cross infections; Drug resistance; Imipenem, therapeutic use; Imipenem, pharmacology

Hrčak ID:

14867

URI

https://hrcak.srce.hr/14867

Publication date:

3.9.2001.

Article data in other languages: croatian

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