Original scientific paper

Distribution of pp'DDT in certain brain regions of rats treated with diazinon

M.A. Matin ; Toxicology Research Centre, Lucknow, U.P. India
R. Agarwal ; Toxicology Research Centre, Lucknow, U.P. India
M.A. Mirza ; Toxicology Research Centre, Lucknow, U.P. India

Abstract

The effect of diazinon, given intraperitoneally, on the distribution of pp'DDT was determined in certain brain regions of rats. pp'DDT concentration expressed per gram of wet weight was highest in the corpus striatum (2575 ng/g) followed by those in the cerebellum (1850 ng/g) and in the cortex (990 ng/g). Pretreatment with diazinon increased pp'DDT accumulation in various brain regions by about 20 per cent (corpus striatum 2995 ng/g; cerebellum 2240 ng/g and cortex 1245 ng/g) and reduced cholinesterase activity by 50 - 70 per cent.

Keywords

Hrčak ID:

152471

URI

https://hrcak.srce.hr/152471

Publication date:

15.6.1989.

Article data in other languages: croatian

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