Short communication, Note
Immunotoxicity of chromium compounds: effect of sodium dichromate on the T cell activation in vitro
E.J. Kucharz
; Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
S.J. Sierakows1ki
; Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Abstract
Human T cells, isolated from peripheral blood of healthy donors, were stimulated with phytohemagglutinin and cultured in vitro in the presence of sodium dichromate (l0-3 - 10-9 M). A high (10-3 M) concentration of sodium dichromate depressed T cell proliferation whereas low levels of dichromate (10-9 M) led to a significant decrease in interleukin 2 production. The results obtained suggest a direct toxic action of sodium dichromate on the functional activity of T cells.
Keywords
Hrčak ID:
153072
URI
Publication date:
19.1.1988.
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