Veterinary Archives, Vol. 86 No. 1, 2016.
Original scientific paper
Structural and ultrastructural evaluation of fibre muscles after exposure to Bisphenol-A, and a study of their possible recovery after treatment with platelet-rich plasma.
Miguel Gimenez
; Department of Comparative Anatomy and Pathological Anatomy, Veterinary Faculty, University of Córdoba, Córdoba, Spain
Ana Molina
; of Córdoba, Córdoba, Spain
Alfonso Blanco
; Department of Comparative Anatomy and Pathological Anatomy, Veterinary Faculty, University of Córdoba, Córdoba, Spain
María Ayala
; Department of Comparative Anatomy and Pathological Anatomy, Veterinary Faculty, University of Murcia, Murcia, Spain
Rosario Moyano
; of Córdoba, Córdoba, Spain
Abstract
Bisphenol-A (BPA) is one of the chemical products most produced in large volumes world-wide. Among other items, it forms part of plastics and food containers, from which there is a migration of BPA into food, thus it enters our organism via the digestive tract, which in fact is one of the main sources of exposure in humans. In this study, BPA action has been investigated: at a muscular level with continuous exposure; after its withdrawal in order to evaluate the possible recovery of the muscle; and the potential effect of platelet-rich plasma (PRP) on a muscle previously modified by the action of BPA. For this purpose, and as a fundamental tool, histopathology was used, from which it was observed that muscle modifications were produced. These were compatible with the action of hormones administered exogenously to animals to fatten them up. It was also noted that, after the withdrawal of BPA, there was some muscle structure recovery, and, after treatment with PRP, this was practically total. Further research should investigate the mechanisms through which BPA affects muscle tissue and PRP succeeds in restoring this type of muscular lesion.
Keywords
bisphenol-A; muscle; histopathology; collagen; platelet-rich plasma
Hrčak ID:
153492
URI
Publication date:
15.2.2016.
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