Professional paper
HORMONE REPLACEMENT THERAPY WITH CLIMEN© AND ITS EFFECTS ON THE BREAST TISSUE
Vesna Antovska
Svetlana Antevska Grujoska
Goran Dimitrov
Vesna Livrinova
Gordana Kiproska
Abstract
Objective. To evaluate the effect of the hormone replacement therapy on breast changes in postmenopausal women. Material and methods. The study includes 35 women with natural or surgical menopause who were treated with sequential estrogen/progestogen hormone replacement therapy (E/P HRT) during one year. The therapeutic program consisted of three weeks treatment with estradiol valerate 2 mg/day orally, combined with ciproterone acetate 1 mg/day in the last 10 days (Climen© – Schering) followed by one week pause. Before the start with E/P HRT basic mammography and ultrasound examination of the breast tissue was performed in all patients. At the end of the study after 12 therapeutic cycles, control mammography and ultrasonographic examination were done. Results. In the short-term study 18 patients (51.43%) showed regression of the finding, 15 (42.86%) stagnation, and only 2 (5.71%) progression of the finding (D=0.27, p<0.01). Conclusion. A clear consensus regarding the relationship between HRT and breast cancer risk cannot yet be drawn.
Keywords
hormone replacement therapy; estrogens; progestogens; breast tissue; mammography; ultrasound
Hrčak ID:
15573
URI
Publication date:
1.3.2004.
Visits: 11.255 *