Original scientific paper

Investigation of the content and ratio of cotinine and nicotine-1'-N-0xide in the urine of smokers

B. Nikolin ; Pharmacy, Institute for Pharmacy and Medicinal Chemistry, University of Sarajevo, Bosnia and Herzegovina
M. Lekić ; Pharmacy, Institute for Pharmacy and Medicinal Chemistry, University of Sarajevo, Bosnia and Herzegovina
A. Rashid Mahmud ; Pharmacy, Institute for Pharmacy and Medicinal Chemistry, University of Sarajevo, Bosnia and Herzegovina
O. Višnjevac ; Pharmacy, Institute for Pharmacy and Medicinal Chemistry, University of Sarajevo, Bosnia and Herzegovina

Abstract

By metabolic degradation of nicotine in the organism of smokers are formed nicotine metabolites such as cotinine, nicotine-1'-N-oxide, nicotine-1,1l'-N-dioxide and others. Recently, special attention has been drawn to the ratios of these metabolites in the biological fluids of diseased smokers. In this work the urinary content of nicotine, cotinine and nicotine-1'-N-oxide was analysed and their ratios were determined. This and other studies suggest that the ratios of these components in urine extracts may play a role in the early diagnosis of the cancer of some organs.

Keywords

Hrčak ID:

157907

URI

https://hrcak.srce.hr/157907

Publication date:

26.9.1984.

Article data in other languages: serbian

Visits: 1.370 *