Original scientific paper
https://doi.org/10.5599/jese.284
Etoricoxib selective sensor based on uracil-5,6-diamino-2-thio hydrochloride as neutral carrier for potentiometric analysis in pharmaceutical preparations
Salwa Fares Rassi
; Department of Chemistry, Faculty of Science, Al-Baath University, Homs, Syria
Abstract
A construction and electrochemical behavior of novel potentiometric membrane sensor responsive to the etoricoxib was described. The sensor was based on the ion-pair complex of etoricoxib (ET) with uracil-5,6-diamino-2-thio hydrochloride (UDTH) (ET-UDTH) as exchange sites in a PVC matrix with different plasticizers dioctyl phthalate (DOPH) (electrode A), dibutyl phthalate (DBPH) (electrode B), and tri-n-butyl phosphate (TBP) (electrode C). The electrodes exhibited near-Nernstian response for ET-UDTH over the concentration range 0.051-40.042 mM. The electrode offered significant advantages including long lifetime (about 2 months), excellent stability and reproducibility, good response time (10-25 s), and wide pH working range (pH 5-12). Selectivity coefficients of ET related to a number of interfering cations and some organic compounds were investigated, and there were negligible interference caused by most of the investigated species. The direct determination of 0.5-10 mM of ET showed an average recovery of 99.03-101.75 % and a mean relative standard deviation 0.40-1.88. The results were obtained by determination of ET in tablets using the proposed electrodes which were comparable favorably with those obtained by spectrophotometric method.
Keywords
Etoricoxib; Uracil-5,6-diamino-2-thio hydrochloride; PVC membrane; Potentiometric method validation
Hrčak ID:
159655
URI
Publication date:
9.6.2016.
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