Acta Pharmaceutica, Vol. 66 No. 4, 2016.
Review article
https://doi.org/10.1515/acph-2016-0039
Side effects of retinoid therapy on the quality of vision
BEATA BERGLER-CZOP
orcid.org/0000-0003-3788-5984
; Department of Dermatology, Medical University of Silesia, 40-027 Katowice, Poland
MONIKA BILEWICZ-STEBEL
; Provincial Specialized Hospital MEGREZ Sp. z o. o., 43-100 Tychy, Poland
ANNA STAŃKOWSK
; Andrzej Mielęcki Silesian Independent Public Clinical Hospital in Katowice, Department of Dermatology, 40-027 Katowice, Poland
TERESA BILEWICZ-WYROZUMSKA
; Department of Environmental Health, School of Public Health in Bytom, Medical University of Silesia, School of Public Health in Bytom, 41-902 Bytom, Poland
Abstract
Retinoids are compounds chemically related to vitamin A, which are frequently used in dermatological practice (1). They are characterized by numerous mechanisms of action leading to normalization of keratinocyte proliferation and maturation. They have anti-seborrhoeic, immunomodulatory and anti-inflammatory effects (1, 2). A number of side- effects to retinoid treatment have been recorded; one group of such side-effects relates to eyes and vision. Dry eye syndrome and blepharoconjunctivitis are the most common side-effects, appearing in 20–50 % of patients treated with retinoids (14). They often contribute to the occurrence of other side-effects such as eye discomfort and contact lens intolerance. Due to widespread use in clinical practice, the adverse effects, including ocular side effects, should be studied. To confirm the variety of adverse effects of retinoids, several case reports of rare side-effects are presented.
Keywords
retinoids; isotretinoin; adverse effects; eyes; acne
Hrčak ID:
161210
URI
Publication date:
31.12.2016.
Visits: 4.611 *