Original scientific paper
The effect of chronic acidosis on bone composition in adult male and female rats
D. Dekanić
; Institute for Medical Research and Occupational Health, Zagreb
Abstract
Four-month old male and female rats received a diet supplemented with 1. 98 per cent of calcium chloride over a period of eight months. Bone changes were analysed by determining weight, volume, density, ash, organic and marrow content of the femur. In chronic acidosis the bone changes observed were generally identical in male and female rats. A development of bones similar in dimensions to those of the control animals but deficient in mineral component was noted. In females this effect of chronic acidosis was still clearly evident after the determination of parameters commonly used to estimate bone composition while in male rats the effect was less obvious. As regards the bone marrow content and bone density sex differences were more evident in the acid loaded than in the control animals. The advantage of using bone without marrow substance is presented.
Keywords
Hrčak ID:
161807
URI
Publication date:
14.6.1979.
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