Case report

THE OXIDATIVE STRESS HYPOTHESIS IN ALZHEIMER’S DISEASE

Manuela Padurariu ; “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
Alin Ciobica ; "Alexandru Ioan Cuza" University, Iasi, Romania; Center of Biomedical Research of the Romanian Academy, Iasi Branch, Romania
Radu Lefter ; "Alexandru Ioan Cuza" University, Iasi, Romania
Ionela Lacramioara Serban ; “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
Cristinel Stefanescu ; “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
Roxana Chirita ; “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania

Abstract

Oxidative stress may be involved in many somatic and psychiatric pathological states including dementia. The hypothesis of
oxidative stress involvement in dementia is supported by much scientific data through biochemical, genetic and molecular studies.
Thus, there are many reports of an increased level of the markers for oxidative damage, alterations in the specific activity of the
antioxidant system, mutations in specific genes, mitochondrial disturbances and also several connections between oxidative stress
and amyloid plaques. Despite these evidence and clinical approaches in using antioxidant therapy in dementia treatment, studies
have failed to prove a clear benefit for antioxidant treatment in dementia. Hence, there is a need for further research regarding
antioxidant therapy in very early stages of dementia.

Keywords

Alzheimer – dementia - oxidative stress - antioxidant

Hrčak ID:

162117

URI

https://hrcak.srce.hr/162117

Publication date:

16.12.2013.

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