Case report

METABOLIC ISSUES IN PSYCHOTIC DISORDERS WITH THE FOCUS ON FIRST-EPISODE PATIENTS: A REVIEW

Dubravka Britvic ; Clinic for Psychiatry, University Clinical Center of Serbia, Belgrade, Serbia
Nadja P. Maric orcid.org/0000-0002-7051-853X ; Clinic for Psychiatry, University Clinical Center of Serbia, Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Mirjana Doknic ; Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Clinic for Endocrinology, University Clinical Center of Serbia, Belgrade, Serbia
Sandra Pekic ; Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Clinic for Endocrinology, University Clinical Center of Serbia, Belgrade, Serbia
Sanja Andric ; Clinic for Psychiatry, University Clinical Center of Serbia, Belgrade, Serbia
Miroslava Jasovic-Gasic ; Clinic for Psychiatry, University Clinical Center of Serbia, Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Vera Popovic ; Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Clinic for Endocrinology, University Clinical Center of Serbia, Belgrade, Serbia

Abstract

Before the onset of the illness, future schizophrenia patients do not weigh more comparing to their peers. However, during the
later course of the illness, obesity is twice as prevalent as in general public, afflicting the half of schizophrenia patient population.
There is a list of potential factors that contribute to this, including lifestyle, dietary habits, unsatisfactory monitoring of physical
health etc, but nowadays side effects of antipsychotic medication become the most prominent concern when weight gain and
metabolic issues in psychosis are addressed.
The fact is that second generation antipsychotics (SGA) are associated with weight gain and metabolic syndrome, but that might
be the case with the first generation antipsychotics (FGA) too. Besides, obesity might be evident in patients before any exposure to
medications, and all that bring lot of dilemmas into the field. This paper critically reviews available data on metabolic problems in
patients with psychotic disorders, raging from genetic to molecular and environmental factors, and highlights the necessity of
screening for the early signs of metabolic disturbances, as well as of multidisciplinary assessment of psychiatric and medical
conditions from the first psychotic episode.

Keywords

antipsychotic agents - first episode – metabolism – obesity – schizophrenia - weight gain

Hrčak ID:

162119

URI

https://hrcak.srce.hr/162119

Publication date:

16.12.2013.

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