Original scientific paper

EFFECT OF ALPHA-LIPOIC ACID SUPPLEMENTATION ON OXIDATIVE STRESS MARKERS AND ANTIOXIDATIVE DEFENSE IN PATIENTS WITH SCHIZOPHRENIA

Bojana Vidović ; University of Belgrade, Faculty of Pharmacy, Department of Bromatology, Belgrade, Serbia
Srđan Milovanović ; University of Belgrade, Faculty of Medicine, Belgrade, Serbia; Clinic for Psychiatry, Clinical Centre of Serbia, Belgrade, Serbia
Brižita Đorđević ; University of Belgrade, Faculty of Pharmacy, Department of Bromatology, Belgrade, Serbia
Jelena Kotur-Stevuljević ; University of Belgrade, Faculty of Pharmacy, Department of Medical Biochemistry, Belgrade, Serbia
Aleksandra Stefanović ; University of Belgrade, Faculty of Pharmacy, Department of Medical Biochemistry, Belgrade, Serbia
Jasmina Ivanišević ; University of Belgrade, Faculty of Pharmacy, Department of Medical Biochemistry, Belgrade, Serbia
Milica Miljković ; University of Belgrade, Faculty of Pharmacy, Department of Medical Biochemistry, Belgrade, Serbia
Slavica Spasić ; University of Belgrade, Faculty of Pharmacy, Department of Medical Biochemistry, Belgrade, Serbia
Dragana Stojanović ; Clinic for Psychiatry, Clinical Centre of Serbia, Belgrade, Serbia
Maja Pantović ; Clinic for Psychiatry, Clinical Centre of Serbia, Belgrade, Serbia

Abstract

Background: The purpose of this study was to examine the effects of alpha-lipoic acid (LA) supplementation on oxidative stress
markers in patients with schizophrenia.
Subjects and methods: Eighteen (18) medicated patients with schizophrenia and 38 healthy controls received daily supplements
of LA (500 mg/day) for three months. At baseline, 45th and 90th days of supplementation, venous blood collected for analysis of
oxidative stress markers [superoxide anion (O2
•-), thiobarbituric acid-reactive substances (TBARS) and advanced oxidation protein
products (AOPP)] and antioxidative defense markers [superoxide dismutase (SOD), total sulfhydryl groups (-SH) and total
antioxidant status (TAS)].
Results: Increased plasma TBARS, TAS, SH groups levels and SOD activity were found in schizophrenic patients compared to
control group. LA supplementation significantly reduced TBARS, AOPP and improved TAS levels in healthy subjects, while there
were no significant differences in patients group. SH groups increased after 45 days and decreased to baseline levels after 90 days of
supplementation in the control group. SOD activity decreased significantly in patients group after 45 days and 90 days of
supplementation. After initial rose SOD activity in control group, decreased to baseline levels found after 90 days.
Conclusion: LA supplementation decreased lipid peroxidation and oxidative damage of proteins and improved non-enzymatic
antioxidant capacity in healthy controls. No significant changes were observed on oxidative damage in patients with schizophrenia.

Keywords

alpha-lipoic acid - oxidative stress - antioxidative defence - schizophrenia

Hrčak ID:

162191

URI

https://hrcak.srce.hr/162191

Publication date:

18.9.2014.

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