Periodicum biologorum, Vol. 118 No. 2, 2016.
Short communication, Note
https://doi.org/10.18054/pb.2016.118.2.3700
The trends of the antioxidant drug “U-74389G” on potassium levels during hypoxia reoxygenation injury in rats
Constantinos Tsompos
orcid.org/0000-0003-3469-3127
; Department of Obstetrics & Gynecology Mesologi County Hospital, Etoloakarnania, Greece
Constantinos Panoulis
; Department of Obstetrics & Gynecology Aretaieion Hospital, Athens University, Attiki, Greece
Konstantinos Toutouzas
; Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece
Aggeliki Triantafyllou
; Department of Biologic Chemistry, Athens University Attiki, Greece
George Zografos
; Department of Surgery Ippokrateion General Hospital, Athens University Attiki, Greece
Apostolos Papalois
; Experimental Research Center ELPEN Pharmaceuticals, S.A. Inc., Co., Attiki Greece
Abstract
Background: This experimental study examined the trends of the antioxidant drug “U-74389G”, on a rat model and particularly in a hypoxia – reoxygenation (HR) protocol. The trends of that molecule were studied biochemically using blood mean potassium levels.
Methods: 40 rats of mean weight 231.875 g were used in the study. Potassium (K+) levels were measured at 60 min of reoxygenation (groups A and C) and at 120 min of reoxygenation (groups B and D) with administration of the drug U-74389G in groups C and D.
Results: U-74389G administration non significantly decreased the K+ levels by 2.14%+5.06% (p= 0.6730). Reoxygenation time non-significantly increased the K+ levels by 8.66%+4.85% (p= 0.0934). However, U-74389G administration and reoxygenation time together non-significantly increased the K+ levels by 2.07%+3.03% (P= 0.4853).
Conclusions: U-74389G administration, reoxygenation time and their interaction have miscellaneous non significant short – term trends on potassium levels. Perhaps, a longer study time or a higher drug dose may reveal clearer and significant effects.
Keywords
hypoxia; U-74389G; potassium; reoxygenation
Hrčak ID:
162222
URI
Publication date:
30.6.2016.
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