Case report

BASIC ASPECTS IN SELECTING A SUITABLE TRANSGENIC RODENT MODEL FOR ALZHEIMER’S DISEASE

Ioana Miruna Balmus ; Department of Biology, "Alexandru Ioan Cuza" University, Iasi, Romania
Alin Ciobica ; Department of Biology, "Alexandru Ioan Cuza" University, Iasi, Romania; Center of Biomedical Research of the Romanian Academy, Iasi Branch, Romania
Anca Negura ; Department of Biology, "Alexandru Ioan Cuza" University, Iasi, Romania; “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
Lucian Negura ; “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
Emil Anton ; “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania

Abstract

Due to Alzheimer’s disease (AD) great aggressiveness, many worldwide health associations began to globalize research efforts
in order to find a suitable treatment and to clarify once and for all its controversial aetiology. Moreover, the animal modelling
research is one of the best tools to evaluate molecular mechanisms and to correlate them with clinical features and behaviours.
However, in order to provide valuable scientific data correlated to low error sources, a rigorous algorithm of selecting the proper
animal model for testing is required. An ideal animal model for AD research has probably not yet been developed, but by a careful
selection of the existent models or even by developing new models suitable to research conditions, consistent progress in this area of
research can be achieved. This paper aims to show and centralize some of the valuable information gathered along the past years of
failure and success in Alzheimer’s disease animal modelling, in order to provide a theoretical ground for new and innovative aspects
in this rather new area of research.

Keywords

animal models - chemical versus transgenic - selection criteria - Alzheimer’s disease

Hrčak ID:

162530

URI

https://hrcak.srce.hr/162530

Publication date:

15.12.2015.

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