Review article

https://doi.org/10.1515/aiht-2016-67-2801

Mutagenic and carcinogenic structural alerts and their mechanisms of action

Alja Plošnik ; National Institute of Chemistry Slovenia, Ljubljana, Slovenia
Marjan Vračko ; National Institute of Chemistry Slovenia, Ljubljana, Slovenia
Marija Sollner Dolenc ; Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia

Abstract

Knowing the mutagenic and carcinogenic properties of chemicals is very important for their hazard (and risk) assessment. One of the crucial events that trigger genotoxic and sometimes carcinogenic effects is the forming of adducts between chemical compounds and nucleic acids and histones. This review takes a look at the mechanisms related to specific functional groups (structural alerts or toxicophores) that may trigger genotoxic or epigenetic effects in the cells. We present up-to-date information about defined structural alerts with their mechanisms and the software based on this knowledge (QSAR models and classification schemes).

Keywords

carcinogenicity; mutagenicity; software prediction; toxicophores

Hrčak ID:

166298

URI

https://hrcak.srce.hr/166298

Publication date:

22.9.2016.

Article data in other languages: slovenian

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