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Collegium antropologicum, Vol. 40 No. 2, 2016.

Original scientific paper

Histopathological Changes in Tracheal Mucosa Following Total Laryngectomy

Marinela Rosso orcid id orcid.org/0000-0002-2460-2247 ; Department of Otorhinolaringology and Head and Neck Surgery, University Hospital Center Osijek, Osijek
Drago Prgomet ; Department of Otorhinolaringology and Head and Neck Surgery, University Hospital Center Zagreb, Zagreb
Ksenija Marjanović ; Institute for Pathology and Forensic Medicine, University Hospital Center Osijek, Osijek
Silvija Pušeljić ; Clinic for Pediatrics, University Hospital Center Osijek, Osijek, Croatia
Robert Tićac ; Department of Otorhinolaringology and Head and Neck Surgery, University Hospital Center Rijeka, Rijeka, Croatia
Ivan Mihaljević ; Clinical Institute of Nuclear Medicine and Radiation Protection, University Hospital Center Osijek, Osijek, Croatia

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Abstract

The aim of this study was to determine the long term histopathologic changes in tracheal mucosa after a total laryngectomy , and to find out the relationship between the progression of histopathologic changes in tracheal mucosa and the duration of breathing through the tracheostomy. Tracheal mucosal biopsies were taken from a total of 35 patients, of both sexes, who underwent a total laryngectomy for laryngeal carcinoma at least one year prior. Histologic specimens of tracheal mucosa were stained with hematoxylin and eosin and examined under light microscopy. Almost all of the patients demonstrated histopathologic changes or abnormalities. Based on the results, histological findings were grouped into seven categories: normal respiratory epithelium, mild, moderate and advanced basal cell hyperplasia, squamous metaplasia, and slight and moderate and dysplasia. The time elapsed since surgery was calculated for each histopathological change separately. In laryngeal carcinoma patients, after a total laryngectomy histopathologic changes occur in tracheal mucosa. The mildest histopathological changes are found in the patients who had a longer period between the operation and the examination.

Keywords

total laryngectomy; tracheal biopsy; laryngeal cancer; tracheostomy; trachea

Hrčak ID:

166690

URI

https://hrcak.srce.hr/166690

Publication date:

28.6.2016.

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