Original scientific paper

Formulation and evaluation of diazepam hydrogel for rectal administration

MARIJA GLAVAS DODOV
KATERINA GORACINOVA
MAJA SIMONOSKA
S. TRAJKOVIC-JOLEVSKA
JASMINA TONIC RIBARSKA
MARIJA DASTEVSKA MITEVSKA

Abstract

Diazepam (DZP) has become a commonly used drug for treatment of acute repetitive epileptic seizures and febrile convulsions in children. Considering the advantages of rectal administration of DZP, the objective of our study was to formulate and evaluate rectal hydrogels containing DZP as a drug substance in combination with suitable co-solvents and preservatives. Prepared HPMC (hydroxypropyl methylcellulose) hydrogels containing different concentrations of DZP (2, 4 and 6 mg mL-1) manifested good quality in respect to physico-chemical parameters (pH value, drug content, ingredients content and viscosity), antimicrobial efficiency and microbiological quality. Under the proposed HPLC conditions, satisfactory separation of DZP and the preservatives used was achieved. In vitro release studies have shown that the total amount of DZP was released in a period of 3 h. Prepared formulations were stable for four months at 26 oC (ambient temperature characteristic of the 2nd climate zone).

Keywords

diazepam; HPMC hydrogel; rectal administration; HPLC determination; stability

Hrčak ID:

16762

URI

https://hrcak.srce.hr/16762

Publication date:

1.9.2005.

Article data in other languages: croatian

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