Acta Pharmaceutica, Vol. 55 No. 3, 2005.
Original scientific paper
Floating microspheres of cimetidine: Formulation, characterization and in vitro evaluation
ANAND KUMAR SRIVASTAVA
DEVENDRA NARAYANRAO RIDHURKAR
SAURABH WADHWA
Abstract
The present study involves preparation and evaluation of floating microspheres with cimetidine as model drug for prolongation of gastric residence time. The microspheres were prepared by the solvent evaporation method using polymers hydroxypropylmethyl cellulose and ethyl cellulose. The shape and surface morphology of prepared microspheres were characterized by optical and scanning electron microscopy, respectively. In vitro drug release studies were performed and drug release kinetics was evaluated using the linear regression method. Effects of stirring rate during preparation, polymer concentration, solvent composition and dissolution medium on the size of microspheres and drug release were also observed. The prepared microspheres exhibited prolonged drug release (~ 8 h) and remained buoyant for > 10 h. The mean particle size increased and drug release rate increased at higher polymer concentration. In vitro studies demonstrated diffusion-controlled drug release from the microspheres. No significant effect of the stirring rate during preparation on drug release was observed.
Keywords
floating microspheres; cimetidine; solvent evaporation; in vitro release; bioavailability
Hrčak ID:
16764
URI
Publication date:
1.9.2005.
Visits: 6.494 *