Short communication, Note

https://doi.org/10.2478/v10007-007-0039-z

Anti-inflammatory and anti-nociceptive activities of Fumaria indica whole plant extract in experimental animals

CHANDANA VENKATESWARA RAO
ARTI RAJ VERMA
PRAKSH KUMAR GUPTA
VIJAYAKUMAR MADHAVAN

Abstract

The 50% ethanolic extract of Fumaria indica was investigated for its anti-inflammatory and antinociceptive potential in animal models. Oral administration of F. indica dry extract (100, 200 and 400 mg kg1) exhibited dose dependent and significant anti-inflammatory activity in acute (carrageenean and histamine induced hind paw oedema – p < 0.05) and chronic (cotton pellet granuloma models of inflammation – p < 0.01). The extract (400 mg kg1) exhibited maximum anti-inflammatory effects of 42.2 and 42.1% after 3 h with carrageenean and histamine respectively. The same dose of extract showed 38.9% reduction in granuloma mass in a chronic condition. A significant anti-nociceptive activity was evidenced in mice; 6.6–67.7% (p < 0.01) protection in mechanical, 33.9–125.1% (p < 0.05) protection in thermal induced pain and 22.2–73.9% (p < 0.05) protection in acetic acid-induced writhing.

Keywords

Fumaria indica (Fumariaceae); anti-inflammatory activity; anti-nociceptive activity

Hrčak ID:

16772

URI

https://hrcak.srce.hr/16772

Publication date:

1.12.2007.

Article data in other languages: croatian

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