Original scientific paper

The protective effects of some tertiary and quarternary antimuscarinic drugs and oxime in rats poisoned by lethal doses of methylethoxy-(2-dimethyl-amino ethylthio)-phosphine oxide

N. Rosić ; Department of Pharmacology and Toxicology, Institute of Technical and Medical Protection, Beograd
V. Vojvodić ; Department of Pharmacology and Toxicology, Institute of Technical and Medical Protection, Beograd
M. Vojvodić ; Department of Pharmacology and Toxicology, Institute of Technical and Medical Protection, Beograd

Abstract

Protective effects of atropine sulphate, 3-quinuclidynil benzilate and their quarternary derivatives were investigated in rats poisoned by lethal doses of organopbosphorous anticholinesterase inhibitor methylethoxy-(2-dimethylaminoethyl thio) - phosphine oxide (33SN). It has been found that 33SN belongs to highly toxic anticholinesterase drugs and its LD50 value for rats (injected subcutaneously) is 0.018 mg/kg. Atropine sulphate, in a dose of 10.0 mg/kg i. p., or 3-quiniclidynil benzilate (5.0 mg/kg, i. p.) given in combination with TMB4 (10.0 mg/kg i. p.), protected rats poisoned by 50 LD50 of 33SN compound. Their quarternary derivatives, however, when given either alone or in combination with TMB4, were markedly less effective in protecting poisoned animals.

Keywords

Hrčak ID:

167730

URI

https://hrcak.srce.hr/167730

Publication date:

18.3.1975.

Article data in other languages: serbian

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