Conference paper
Changes in drug metabolism and lipoproteins in workers occupationally exposed to DDT and lindane
Brigitta Kolmodin-Helman
; Department of Occupational Health, National Board of Occupational Health, Stockholm, and Department of Clinical Pharmacology and Department of Toxicology, Karolinska Institutet, Stockholm
Abstract
In twenty-six men occupationally exposed mainly to lindane and DDT antipyrine had a significantly shorter plasma half-life than in 33 control subjects. Twenty-two men exposed mainly to lindane and DDT in their occupation and 19 healthy male persons were studied with regard to their fasting serum lipid levels and to the amounts of lipids in the three ultracentrifugally separated lipoprotein families, VLDL, LDL and HDL. Eight of the exposed subjects and none of the controls had hyper-HDL (a)-lipoproteinemia. Plasma levels of Iiridane, p,p'-DDE and p,p'-DDT were determined with a new gas chromatographic method in fourty-two spraymen exposed to lindane and in twenty-three nursery workers with a low and intermittent exposure to DDT. Controls were eleven and twenty-one respectively. The plasma lindane levels of the exposed groups differed significantly (p < 0.001) from the non-exposed ones. The plasma DDE and DDT values of the exposed persons did not differ from controls with only low dietary exposure to DDT. No changes in the clinical state of health could be recorded in any of the examined groups.
Keywords
Hrčak ID:
168410
URI
Publication date:
19.3.1974.
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