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Croatian Medical Journal, Vol. 57 No. 2, 2016.

Original scientific paper

https://doi.org/10.3325/cmj.2016.57.141

Helicobacter pylori in sedentarymen is linked to higher heart rate, sympathetic activity, and insulin resistance but not inflammation or oxidative stress

Andriy Cherkas orcid id orcid.org/0000-0002-6652-6983 ; Department of Internal Medicine No.1, Danylo Halytskyi Lviv National Medical University, Lviv, Ukraine
Peter Eckl ; Department of Cell Biology, University of Salzburg, Salzburg,Austria
Françoise Guéraud ; Toxalim, Université de Toulouse INRA, INP-ENVT, INP-EI-Purpan, Université de Toulouse 3 PaulSabatier, Toulouse, France
Orest Abrahamovych ; Department of Internal Medicine No.1, Danylo Halytskyi Lviv National Medical University, Lviv, Ukraine
Victoria Serhiyenko ; Department of Endocrinology Danylo Halytskyi Lviv NationalMedical University, Lviv, Ukraine
Ostap Yatskevych ; Department of Internal Medicine No.1, Danylo Halytskyi Lviv National Medical University, Lviv, Ukraine
Mykhailo Pliatsko ; Department of Internal Medicine No.1, Danylo Halytskyi Lviv National Medical University, Lviv, Ukraine
Sergii Golota ; Organic and Bioorganic Chemistry,Danylo Halytskyi Lviv National, Medical University, Lviv, UkraineDepartment of Pharmaceutical

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Abstract

Aim To compare anthropometric parameters, body composition,
hormonal and inflammatory profiles, oxidative
stress indices, and heart rate variability (HRV) in Heliobacter
pylori (H.pylori) positive and negative healthy sedentary
participants.
Methods Among 30 recruited apparently healthy male
participants (age between 20 and 40) enrolled in this
cross-sectional study, 18 were H.pylori negative and 12
were positive (stool antigen test). Participants underwent
routine physical examination and body composition determination.
The following biochemical parameters were
determined in blood: fasting whole blood glucose, glycated
hemoglobin, insulin, C-peptide, cortisol, aldosterone,
testosterone, thyroid stimulating hormone, C-reactive protein,
interleukins 6 and 10, tumor necrosis factor-α, and the
urinary level of 1,4-dihydroxynonane mercapturic acid. For
HRV evaluation, electrocardiogram in supine position and
in orthostatic test was performed.
Results H.pylori contamination was not significantly associated
with any changes in anthropometric parameters,
body composition, blood pressure, fasting glucose,
or glycated hemoglobin levels. No significant difference
was found for inflammatory markers as well as 1,4-dihydroxynonane
mercapturic acid. H.pylori-positive participants,
however, had significantly higher heart rate
(P = 0.009), sympathetic/parasympathetic balance in orthostatic
test (P = 0.029), fasting insulin level (P = 0.037), and
HOMA-index (P = 0.047).
Conclusions H.pylori contamination is linked to a significantly
higher heart rate, sympathetic activation, and increased
insulin resistance, while inflammatory and oxidative
stress markers remain unaffected in healthy sedentary
male subjects.

Keywords

Hrčak ID:

169487

URI

https://hrcak.srce.hr/169487

Publication date:

15.4.2016.

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