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Croatian Medical Journal, Vol. 57 No. 3, 2016.

Original scientific paper

https://doi.org/10.3325/cmj.2016.57.266

Joint and fascial chronic graftvs- host disease: correlations with clinical and laboratory parameters

Tamara Vukić ; Department of Rehabilitation and Orthopaedic Aids, UniversityHospital Center Zagreb, Zagreb, Croatia
Sean Robinson Smith ; Department of Physical Medicine and Rehabilitation, University ofMichigan, Ann Arbor, MI, USA
Dina Ljubas Kelečić ; Clinical Unit for Clinical Nutrition Department of Internal Medicine,University Hospital Center ZagrebZagreb, Croatia
Lana Desnica ; Division of Hematology Department of Internal MedicineUniversity Hospital Center Zagreb,Zagreb, Croatia
Ema Prenc ; Croatian Cooperative Group for Hematologic Diseases (CroHem), Zagreb, Croatia
Dražen Pulanić ; Division of Hematology Department of Internal MedicineUniversity Hospital Center Zagreb,Zagreb, Croatia
Radovan Vrhovac ; Division of Hematology Department of Internal MedicineUniversity Hospital Center Zagreb,Zagreb, Croatia
Damir Nemet ; Division of Hematology Department of Internal MedicineUniversity Hospital Center Zagreb,Zagreb, Croatia
Steven Z. Pavletic ; Experimental Transplantation and Immunology Branch, NationalCancer Institute, Center for CancerResearch, National Institutes ofHealth, Bethesda, MD, USA

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Abstract

Aim To determine if there are correlations between joint
and fascial chronic graft-vs-host disease (cGVHD) with clinical
findings, laboratory parameters, and measures of functional
capacity.
Methods 29 patients were diagnosed with cGVHD based
on National Institutes of Health (NIH) Consensus Criteria at
the University Hospital Centre Zagreb from October 2013
to October 2015. Physical examination, including functional
measures such as 2-minute walk test and hand grip
strength, as well as laboratory tests were performed. The
relationship between these evaluations and the severity of
joint and fascial cGVHD was tested by logistical regression
analysis.
Results 12 of 29 patients (41.3%) had joint and fascial
cGVHD diagnosed according to NIH Consensus Criteria.
There was a significant positive correlation of joint and
fascial cGVHD and skin cGVHD (P < 0.001), serum C3 complement
level (P = 0.045), and leukocytes (P = 0.032). There
was a significant negative correlation between 2-minute
walk test (P = 0.016), percentage of cytotoxic T cells CD3+/
CD8+ (P = 0.022), serum albumin (P = 0.047), and Karnofsky
score (P < 0.001). Binary logistic regression model found
that a significant predictor for joint and fascial cGVHD was
cGVHD skin involvement (odds ratio, 7.79; 95 confidence
interval 1.87-32.56; P = 0.005).
Conclusion Joint and fascial cGVHD manifestations correlated
with multiple laboratory measurements, clinical features,
and cGVHD skin involvement, which was a significant
predictor for joint and fascial cGVHD

Keywords

Hrčak ID:

170149

URI

https://hrcak.srce.hr/170149

Publication date:

15.6.2016.

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