Short communication, Note

The prognostic value of the hydroxyamylobarbitone / amylobarbitone ratio

J. Grove ; Poisons Unit, New Cross Hospital, and Department of Clinical Chemistry, Guy's Hospital, London
P.A. Toseland ; Poisons Unit, New Cross Hospital, and Department of Clinical Chemistry, Guy's Hospital, London

Abstract

An accurate, precise and rapid method for the determination of hydroxyamylobarbitone in urine and plasma has been reported previously. Further studies on the excretion of amylobarbitone and hydroxyamylobarbitone in cases of therapeutic ingestion, overdose and death from amylobarbitone have led to the introduction of a new concept, the urinary ratio of the concentration of hydroxyamylobarbitone/amylobarbitone. Its significance when associated with measurable blood amylobarbitone levels has led to the suggestion that this ratio may be more indicative of the patient's condition than that of a blood barbiturate level viewed in isolation. Ratios for patients ingesting 200 mg of sodium amylobarbitone were in the range 0-43,8 without measurable blood levels. Overdoses fell within the range 8.8-92.5 with measurable blood levels, the lower ratios being associated with the deepest coma. Very low ratios between 0 and 15.4 were found from cases of death again with detectable barbiturate in the blood

Keywords

Hrčak ID:

172849

URI

https://hrcak.srce.hr/172849

Publication date:

10.3.1971.

Article data in other languages: croatian

Visits: 1.149 *