Original scientific paper

Circular Dichroism and Absorption Spectra of Monoand Di-Aminoacridines Complexed to DNA

Daniel Fornasiero ; Department of PhysicaL and Inorganic Chemistry, University of Adelaide, Adelaide 5001, South Australia
Tomas Kurucsev ; Department of PhysicaL and Inorganic Chemistry, University of Adelaide, Adelaide 5001, South Australia
Reidar Lyng ; Department of Physical Chemistry, Chalmers University of Technology, S-412 96 Gothenburg, Sweden
Bengt Norden ; Department of Physical Chemistry, Chalmers University of Technology, S-412 96 Gothenburg, Sweden

Abstract

The absorption and circular dichroism spectra of the intercalation
complexes with DNA of the 9-aminoacridine chromophore
in mono- and bisfunctional forms have been determined in the
visible/near-ultraviolet region. The experimental spectra were
deconvoluted into contributions from three (It*, n) transitions and
the dipole and rotatory strengths of one long-axis and one shortaxis
polarized transition were determined for each intercalating
species. The experimental results were compared with theoretical
calculations of the induced CD of intercalation complexes and a
series. of inferences were drawn concerning the geometry of the
complexes.

Keywords

Hrčak ID:

175500

URI

https://hrcak.srce.hr/175500

Publication date:

10.8.1989.

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