Other

Antibiotic-induced toxic epidermal necrolysis - a case report

Tino Klancir ; 1Department of Anesthesiology, Reanimatology and Intensive Care, Clinical hospital Sveti Duh, Zagreb, Croatia
Višnja Nesek Adam ; 1Department of Anesthesiology, Reanimatology and Intensive Care, Clinical hospital Sveti Duh, Zagreb, Croatia, 2Josip Juraj Strossmayer University of Osijek, School of Medicine, Osijek, Croatia
Martina Matolić ; 1Department of Anesthesiology, Reanimatology and Intensive Care, Clinical hospital Sveti Duh, Zagreb, Croatia
Elvira Grizelj Stojčić ; 1Department of Anesthesiology, Reanimatology and Intensive Care, Clinical hospital Sveti Duh, Zagreb, Croatia,
Maja Karaman Ilić ; 1Department of Anesthesiology, Reanimatology and Intensive Care, Clinical hospital Sveti Duh, Zagreb, Croatia, 2Josip Juraj Strossmayer University of Osijek, School of Medicine, Osijek, Croatia

Abstract

Toxic epidermal necrolysis (TEN) is severe cutaneous

Toxic epidermal necrolysis (TEN) is severe cutaneous hypersensitivity reaction characterized by necrosis of the epidermis and detachment of the epidermis and dermis that usually occurs as an idiosyncratic reaction to certain drugs. We report the case of a patient admitted to our Intensive Care Unit after an above-the-knee amputation who developed toxic epidermal necrolysis, possibly resulting from antibiotics therapy. Therapy included a combination of intravenous immunoglobulin with gentle early debridement of necrotic skin areas followed by wound coverage with a synthetic cover (Aquacel Ag®). This case report suggests that intensive wound management together with intravenous immunoglobulin might be beneficial in the treatment of patients with TEN.

Keywords

Hrčak ID:

180909

URI

https://hrcak.srce.hr/180909

Publication date:

5.5.2017.

Visits: 1.791 *