Acta Pharmaceutica, Vol. 55 No. 4, 2005.
Original scientific paper
Toxic effects of Ustilago maydis and fumonisin B1 in rats
STJEPAN PEPELJNJAK
JÓZSEF PETRIK
MAJA ŠEGVIĆ KLARIĆ
Abstract
Ustilago maydis and FB1 showed neurotoxicity in Fischer rats, which was indicated by hyperactivity, brain hyperaemia and especially by decreased AChE activity. These pathological changes could be related to the alkaloids of U. maydis and disruption of sphingolipid metabolism by FB1 activity. Pathological changes in liver, lungs, uterus and ovaries were more pronounced in the US+FB1 than in the US group, indicating possible synergism. Increased activity of LDH in the serum was observed only in the US+FB1 group, which led to the conclusion that FB1 is responsible for cytotoxic effects. Such activity of FB1 could increase the toxicity of U. maydis and other co-contaminants of fungal origin that can be found in foods and feeds.
Keywords
Ustilago maydis; fumonisin B1; neurotoxycity; cytotoxicity
Hrčak ID:
18117
URI
Publication date:
1.12.2005.
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