Original scientific paper
https://doi.org/10.1515/aiht-2017-68-2905
Lycopene restores trace element levels in ochratoxin A-treated rats
Saziye Sezin Palabiyik
; Ataturk University, Faculty of Pharmacy, Department of Toxicology, Erzurum, Turkey
Pinar Erkekoglu
; Hacettepe University, Faculty of Pharmacy, Department of Toxicology, Ankara, Turkey
Murat Kızılgun
; Diskapi Children’s Hospital, Department of Biochemistry, Ankara, Turkey
Gonul Sahin
; Eastern Mediterranean University, Faculty of Pharmacy, Department of Toxicology, Mersin, Turkey
Belma Kocer-Gumusel
; Hacettepe University, Faculty of Pharmacy, Department of Toxicology, Ankara, Turkey
Abstract
This study was designed to investigate the in vivo effects of ochratoxin A (OTA) and/or lycopene on the levels of selenium, zinc, and copper in the liver, kidneys, and testes of male Sprague-Dawley rats. The rats were treated with OTA (0.5 mg kg-1 day-1) and/or lycopene (5 mg kg-1 day-1) by gavage for 7 or 14 days. Trace element levels were measured by atomic absorption spectrometry. OTA significantly lowered selenium (20 % in the liver, 17 % in the kidney, and 40 % in the testis), zinc (24 % in the liver, 23 % in the kidney, and 26 % in the testis), and copper levels (40 % in the liver and 10 % in the kidney). Lycopene alone did not affect the trace element levels in any of the organs. In combination with OTA, however, it significantly restored liver, kidney, and testis selenium and zinc levels compared to the group treated with OTA alone. Our results have confirmed that depletion of trace elements in different organs is one of the mechanisms of action of OTA. They also suggest that lycopene interferes with this depleting effect and restores trace element levels, the implications of which need to be further investigated.
Keywords
copper; kidney; liver; mycotoxins; selenium; testis; zinc
Hrčak ID:
183267
URI
Publication date:
20.6.2017.
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