Original scientific paper
https://doi.org/10.5599/jese.382
Square wave and differential pulse voltammetric methods for the analysis of olivetol at gold electrode
Jyoti T. Bagalkoti
; P.G. Department of Studies in Chemistry, Karnatak University, Dharwad 580 003, India
Vijay P. Pattar
; P.G. Department of Studies in Chemistry, Karnatak University, Dharwad 580 003, India
Sharanappa T. Nandibewoor
; P.G. Department of Studies in Chemistry, Karnatak University, Dharwad 580 003, India
Abstract
Few electrochemical techniques have been employed for the determination of the powerful antitumor agent olivetol (OLV) in real samples at gold electrode. An intense and well pronounced oxidation peak was obtained at 1.04 V in the phosphate buffer pH 5.0 as the supporting electrolyte. The effects of pH and scan rate on the oxidation peak were studied. The electrochemical behavior of OLV was investigated using cyclic voltammetric (CV), square wave voltammetric (SWV) and differential pulse voltammetric (DPV) techniques. In DPV and SWV, the gold electrode showed a good sensitivity for OLV in a linear range of 0.1-1.5 μM and 0.1-1.3 μM and detection limits of 1.936×10-9 M and 4.754×10-9 M, respectively. A plausible mechanism involving an adsorption controlled oxidation reaction was deduced. The effect of various excipients was also studied and the method was successfully applied for the determination of OLV in human biological samples.
Keywords
Olivetol; electrooxidation; voltammetric techniques; gold electrode
Hrčak ID:
183519
URI
Publication date:
28.6.2017.
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